Hormone
leuprolide acetate
[ loo-proh-lide a-seh-tayt ]
Effect:
Decreased Follicle Stimulating Hormone Secretion; Decreased GnRH Secretion; Decreased Luteinizing Hormone Secretion; Decreased Ovarian Estrogen Secretion; Decreased Testosterone Secretion
May Treat:
Breast Neoplasms;
Endometrial Neoplasms;
Endometriosis;
Infertility;
Leiomyoma;
Ovarian Neoplasms;
Prostatic Hyperplasia;
Prostatic Neoplasms;
Puberty, Precocious
More Information:
Definitions related to leuprolide acetate:
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A drug used to treat symptoms of advanced prostate cancer. It is also being studied in the treatment of other conditions and types of cancer. The active ingredient leuprolide blocks the body from making testosterone (a male hormone) and estradiol (a female hormone). It may stop the growth of prostate cancer cells that need testosterone to grow. Some brands of leuprolide are also used to treat early puberty in children and certain gynecologic conditions. Leuprolide acetate is a type of gonadotropin-releasing hormone analog.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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The acetate salt of a synthetic nonapeptide analogue of gonadotropin-releasing hormone. Leuprolide binds to and activates gonadotropin-releasing hormone (GnRH) receptors. Continuous, prolonged administration of leuprolide in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. This agent reduces testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression.NCI ThesaurusU.S. National Cancer Institute, 2021
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