Pharmacologic Substance
reserpine
res·er·pine [ res-er-pin, -peen, ruh-sur-pin, -peen ]
Effect:
Decreased Blood Pressure; Decreased Sympathetic Norepinephrine Activity
May Treat:
Dyskinesias;
Hypertension;
Schizophrenia
More Information:
Definitions related to reserpine:
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Alkaloid isolated from the root of Rauwolfia species, used as an antihypertensive and sedative.CRISP ThesaurusNational Institutes of Health, 2006
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An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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An alkaloid, derived from the roots of Rauwolfia serpentine and vomitoria, and an adrenergic uptake inhibitor with antihypertensive effects. Reserpine is lipid soluble and can penetrate blood-brain barrier. This agent binds and inhibits catecholamine pump on the storage vesicles in central and peripheral adrenergic neurons, thereby inhibiting the uptake of norepinephrine, dopamine serotonin into presynaptic storage vesicles. This results in catecholamines and serotonin lingering in the cytoplasm where they are destroyed by intraneuronal monoamine oxidase, thereby causing the depletion of catecholamine and serotonin stores in central and peripheral nerve terminals. Depletion results in a lack of active transmitter discharge from nerve endings upon nerve depolarization, and consequently leads to a decreased heart rate and decreased arterial blood pressure as well as sedative effects.NCI ThesaurusU.S. National Cancer Institute, 2021
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Reserpine, drug derived from the roots of certain species of the tropical plant Rauwolfia. The powdered whole root of the Indian shrub Rauwolfia serpentina historically had been used to treat snakebites, insomnia, hypertension (high blood pressure), and insanity. Reserpine, isolated in 1952, was...Encyclopedia Britannica, Inc., 2020
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